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High Fever Manifestation During Acute Infections Coincides with Improvement in Autism Spectrum Disorder (ASD) While Under Classical Homeopathy, A Case Report

The patient, a 2-year-9-month-old Indian boy, presented for homeopathic consultation in October 2015. The diagnosis of mild to moderate ASD was made for him in March 2015. He was given speech and language therapy, which was stopped six months into homeopathic treatment.

 

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High Fever Manifestation During Acute Infections Coincides with Improvement in Autism Spectrum Disorder (ASD) While Under Classical Homeopathy, A Case Report

 

Authors Jaggi A, Jaggi L, Batra M , Mahesh S , Vithoulkas G

Received 21 November 2025

Accepted for publication 16 March 2026

Published 27 March 2026 Volume 2026:17 583452

DOI https://doi.org/10.2147/PHMT.S583452

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Laurens Holmes, Jr

 

Clinical Research Division, H3 Centre of Classical Homeopathy, Nashik, Maharashtra, India; 2Research Division, Blessed Cure – Healing with Homeopathy, Gurugram, Haryana, India; 3Research Department, Centre for Classical Homeopathy, Bangalore, Karnataka, India; 4Scientific Research Department, International Academy of Classical Homeopathy, Alonissos, Greece; 5Homeopathy Department, University of the Aegean, Mytilene, Greece

Correspondence: Seema Mahesh, Centre for Classical Homeopathy, No. 10, 6th Cross, Opp HP Petrol Bunk, Chandra Layout, Vijayanagar, Bangalore, Karnataka, 560040, India, Tel +91 9449084747, Email bhatseema@hotmail.com

Purpose: This case study investigates the relevance of the continuum theory of diseases in the context of autism spectrum disorder (ASD). The aim is to illustrate a real-world observation that aligns with the theory’s premise regarding the therapeutic role of acute illness in chronic conditions.
Methodology/Approach: It details a case of mild to moderate ASD in a child aged 2 years and 9 months with a long-term follow-up. The patient received individualized classical homeopathic treatment (where selection of a remedy is based on the patient’s individualized symptom profile and totality of characteristic symptoms), and progress was evaluated using the Childhood Autism Rating Scale (CARS) and the Communication DEALL Developmental Checklist (CDDC).
Results: The patient showed significant improvement in all developmental domains. The interesting observation was that the improvement in the clinical features in this case of ASD was apparent after the onset of previously absent common acute infections with fever.
Conclusion: The observed phenomenon corresponds with the continuum theory of diseases. This suggests that a transition in the immune system profile from chronic to acute inflammation may correlate with improved outcomes for individuals with ASD. Further scientific studies are required to determine the connection between chronic and acute inflammation to preserve the immune system’s efficiency and promote therapies that do not inadvertently perpetuate chronic inflammation.

Keywords: autism spectrum disorder, homeopathy, inflammation, fever, neurodevelopmental disorders

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