Organon aphorism §273
In no case under treatment is it necessary and THEREFORE NOT PERMISSIBLE to administer to a patient more than ONE SINGLE, SIMPLE MEDICINAL substance at one time. It is inconceivable how the slightest doubt could exist as to whether it was more consistent with nature and more rational to prescribe a SINGLE, SIMPLE ( 159 ) medicine at one time in a disease or a mixture of several differently acting drugs. It is absolutely not allowed in homeopathy, the one true, simple and natural art of healing, to give the patient AT ONE TIME two different medicinal substances.
Organon aphorism §274
As the true physician finds in simple medicines, administered singly and uncombined, all that he can possibly desire (artificial disease-forces which are able by homeopathic power completely to overpower, extinguish, and permanently cure natural diseases), he will, mindful of the wise maxim that "it is wrong to attempt to employ complex means when simple means suffice," never think of giving as a remedy any but a single, simple medicinal substance; for these reasons also, because even though the simple medicines were THOROUGHLY PROVED with respect to their pure peculiar effects on the unimpaired healthy state of man, it is yet impossible to foresee HOW two and more medicinal substances might, when compounded, hinder and alter each other's actions on the human body; and because, on the other hand, a simple medicinal substance when used in diseases, the totality of whose symptoms is accurately known, renders efficient aid by itself alone, if it be homeopathically selected; and supposing the worst case to happen, that it was not chosen in strict conformity to similarity of symptoms, and therefore does no good, it is yet so far useful that it promotes our knowledge of therapeutic agents, because, by the new symptoms excited by it in such a case, those symptoms which this medicinal substance had already shown in experiments, on the healthy human body are confirmed, an advantage that is lost by the employment of all compound remedies. ( 160 )
Organon aphorism §275
The suitableness of a medicine for any given case of disease does not depend on its accurate homeopathic selection alone, but likewise on the proper size, or rather smallness, of the dose. If we give TOO STRONG A DOSE of a medicine which may have been even quite homeopathically chosen for the morbid state before us, it must, notwithstanding the inherent beneficial character of its nature, prove injurious by its mere magnitude, and by the unnecessary, too strong impression which, by virtue of its homeopathic similarity of action, it makes upon the vital force which it attacks and, through the vital force, upon those parts of the organism which are the most sensitive, and are already most affected by the natural disease.
Organon aphorism §276
For this reason, a medicine, even though it may be homeopathically suited to the case of disease, does harm in every dose that is too large, and in strong doses it does more harm the greater its homeopathicity and the higher the potency ( 161 ) selected, and it does much more injury than any equally large dose of a medicine that is unhomeopathic and in no respect adapted to the morbid state (allopathic) .
Too large doses of an accurately chosen homeopathic medicine, and especially when frequently repeated, bring about much trouble as a rule. They put the patient not seldom in danger of life or make his disease almost incurable. They do indeed extinguish the natural disease so far as the sensation of the life principle is concerned and the patient no longer suffers from the original disease from the moment the too strong dose of the homeopathic medicine acted upon him but he is in consequence more ill with the similar but more violent medicinal DISEASE WHICH is most difficult to destroy. ( 162 )
Organon aphorism §277
For the same reason, and because a medicine, provided the dose of it was sufficiently small, is all the more salutary and almost marvellously efficacious the more accurately homeopathic its selection has been, a medicine whose selection has been accurately homeopathic must be all the more salutary the more its dose is reduced to the degree of minuteness appropriate for a gentle remedial effect.
Organon aphorism §278
Here the question arises, what is this most suitable degree of minuteness for sure and gentle remedial effect; how small, in other words, must be the dose of each individual medicine, homeopathically selected for a case of disease, to effect the best cure? To solve this problem, and to determine for every particular medicine, what dose of it will suffice for homeopathic therapeutic purposes and yet be so minute that the gentlest and most rapid cure may be thereby obtained—to solve this problem is, as may easily be conceived, not the work of theoretical speculation; not by fine-spun reasoning, not by specious sophistry, can we expect to obtain the solution of this problem. It is just as impossible as to tabulate in advance all imaginable cases. Pure experiment, careful observation of the sensitiveness of each patient, and accurate experience can alone determine this IN EACH INDIVIDUAL CASE, and it were absurd to adduce the large doses of unsuitable (ALLOPATHIC) medicines of the old system, which do not touch the diseased side of the organism homeopathically, but only attack the parts unaffected by the disease, in opposition to what pure experience pronounces respecting the smallness of the doses required for homeopathic cures.
Organon aphorism §279
This pure experience shows UNIVERSALLY, that if the disease do not manifestly depend on a considerable deterioration of an important viscus (even though it belong to the chronic and complicated diseases), and if during the treatment all other alien medicinal influences are kept away from the patient, THE DOSE OF THE HOMEOPATHICALLY SELECTED AND HIGHLY POTENTIZED REMEDY for the beginning of treatment of an important, especially chronic disease can never be prepared so small that it shall not be stronger than the natural disease and shall not be able to overpower it, at least in part and extinguish it from the sensation of the principle of life and thus make a beginning of a cure.
Organon aphorism §280
The dose of the medicine that continues serviceable without producing new troublesome symptoms is to be continued while GRADUALLY ASCENDING, so long as the patient WITH GENERAL IMPROVEMENT, begins to feel in a mild degree the return of one or several old original complaints. This indicates an approaching cure through a gradual ascending of the moderate doses modified each time by succussion (§ 247). It indicates that the vital principle no longer needs to be affected by the similar medicinal disease in order to lose the sensation of the natural disease (§ 148). It indicates that the life principle now free from the natural disease begins to suffer only something of the medicinal disease hitherto known as HOMEOPATHIC AGGRAVATION.
Organon aphorism §281
In order to be convinced of this, the patient is left without any medicine for eight, ten or fifteen days, meanwhile giving him only some powders of sugar of milk. If the few last complaints are due to the medicine simulating the former original disease symptoms, then these complaints will disappear in a few days or hours. If during these days without medicine, while continuing good hygienic regulations nothing more of the original disease is seen, he is probably cured. But if in the later days traces of the former morbid symptoms should show themselves, they are remnants of the original disease not wholly extinguished, which must be treated with renewed higher potencies of the remedy as directed before. If a cure is to follow, the first small doses must likewise be again gradually raised higher, but less and more slowly in patients where considerable irritability is evident than in those of less susceptibility, where the advance to higher dosage may be more rapid. There are patients whose impressionability compared to that of the unsusceptible ones is like the ratio as 1000 to 1.
Organon aphorism §282
It would be a certain sign that the doses were altogether too large, if during treatment, especially in chronic diseases, the first dose should bring forth a so-called HOMEOPATHIC AGGRAVATION, that is, a marked increase of the original morbid symptoms first discovered and in the same way every repeated dose (p. 247) however modified somewhat by shaking before its administration (I. E., more highly dynamized). ( 163 )
Organon aphorism §283
In order to work wholly according to nature, the true healing artist will prescribe the accurately chosen homeopathic medicine most suitable in all respects in so small a dose on account of this alone. For should he be misled by human weakness to employ an unsuitable medicine, the disadvantage of its wrong relation to the disease would be so small that the patient could through his own vital powers and by means of early opposition (p. 249) of the correctly chosen remedy according to symptom similarity (and this also in the smallest dose) rapidly extinguish and repair it.
Organon aphorism §284
Besides the tongue, mouth and stomach, which are most commonly affected by the administration of medicine, the nose and respiratory organs are receptive of the action of medicines in fluid form by means of olfaction and inhalation through the mouth. But the whole remaining skin of the body clothed with epidermis, is adapted to the action of medicinal solutions, especially if the inunction is connected with simultaneous internal administration. ( 164 )
Organon aphorism §285
In this way, the cure of very old diseases may be furthered by the physician applying externally, rubbing it in the back, arms, extremities, the same medicine he gives internally and which showed itself curatively. In doing so, he must avoid parts subject to pain or spasm or skin eruption. ( 165 )