Correlation between absence of efficient acute inflammatory response and multiple sclerosis, a pilot study
(Oral Presentation - Our poster was selected as one of the best abstracts and given a video presentation opportunity - you will see the video below)
Authors: Seema Mahesh1, Vitalie Vacaras2 and George Vithoulkas3
1Centre for Classical Homeopathy, Vijayanagar Bangalore, India,
2University of Medicine and Pharmacy, Iuliu Hatieganu, Cluj-Napoca, Romania and
3University of the Aegean International Academy of Classical Homeopathy, Alonissos, Greece
Abstract topic: Emerging concepts for understanding and treating patients with neuroinflammation and neurodegeneration, with a particular focus on multiple sclerosis
Background: Efficient acute inflammatory response, signified by the ability to mount a high fever during common infections is the hallmark of a healthy immune system (1-4). Inability to do so eventually leads to disrupted resolution of the inflammation and the perpetuation of a low grade chronic inflammatory state (5-9). This phenomenon may be operational in the triggering of many chronic diseases including Multiple sclerosis (MS) (7, 10), and may be worsened by the abuse of antibiotics (11, 12), which further suppress the inflammatory response.
Objective: To investigate if MS patients exhibited a history of efficient acute inflammatory response, marked by high fever (>38oC), and the prevalence of antibiotic use, in their past history
Methods: We collected data from 100 consenting MS patients visiting the Department of Neurosciences, County Emergency Hospital, Cluj-Napoca in Romania, regarding the past history of treatment of acute infections. The patients included 77 females and 23 males, ranging from 21 to 61 years of age (average age of 39.26). The maximum Expanded Disability Status Scale was 5.5.
Results: Of 100 cases, 80 cases showed a history of recurrent acute infections treated with antibiotics. 12 cases showed a history of acute infections, but without antibiotic treatment and six cases had no history of acute infections. Two cases could not provide the data with certainty. High fever (>38o C) was exhibited by six cases, while 53 cases showed low grade fevers during their acute infections and 40 cases developed no fevers. One case could not provide data.
Conclusion: Reduced ability to mount an acute inflammatory response during acute infections may be predictive of a low grade chronic inflammatory disease such as MS. The abuse of antibiotics was also rampant in the history of these patients These findings need deeper scientific investigation into all the parameters involved, including the repeated treatment with antibiotics
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