13TH INTERNATIONAL CONGRESS ON AUTOIMMUNITY, 2022
IACH - Prof. G. Vithoulkas
13TH INTERNATIONAL CONGRESS ON AUTOIMMUNITY, 2022

Topic: Immunomodulation

Title: CORRELATION BETWEEN ACUTE AND CHRONIC INFLAMMATORY STATES, A CASE CONTROL STUDY

Seema Mahesh*, Mahesh Mallappa, Vitalie Vacaras, Viraj Shah, Amritha Belagaje, Pooja Dhamodar, Elena Serzhantova, Nadezhda Kubasheva, Dmitriy Chabanov, Dionysios Tsintzas, Latika Jaggi, Atul Jaggi, George Vithoulkas.

Presenting author:

1 Seema Mahesh

School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Malaysia

Centre For Classical Homeopathy, Bangalore, India

Tel: +91 9449084747

Author and co-author’s details:

2 Mahesh Mallappa

Centre for Classical Homeopathy, Bangalore, India

3 Vitalie Vacaras

Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania

4 Viraj Shah

Shah Homeopathic Clinic, Vastrapur, Ahmedabad, India

5 Amritha Belagaje

Centre for Classical Homeopathy, Bangalore, India

6 Pooja Dhamodar

Centre for Classical Homeopathy, Bangalore, India

7 Elena Serzhantova

Novosibirsk Centre of Classical Homeopathy, Novosibirsk, Russia

8 Nadezhda Kubasheva

Clinic of Nadezhda Kubasheva, Moscow Russia

9 Dmitriy Chabanov

Novosibirsk Centre of Classical Homeopathy, Novosibirsk, Russia

10 Dionysios Tsintzas

General Hospital of Aitoloakarnania, Agrinion, Greece

11 Latika Jaggi

H3 Centre of Classical Homeopathy, Nashik, India

12 Atul Jaggi

H3 Centre of Classical Homeopathy, Nashik, India

13 George Vithoulkas

University of the Aegean, Syros, Greece

Postgraduate Doctors' Training Institute, Health Care Ministry of the Chuvash Republic, Cheboksary, Russian Federation

Preferred Presentation type: Oral presentation

Background and aim:

Suppression of efficient acute inflammation may be one of the mechanisms behind the onset of chronic low-grade inflammation. Efficient acute inflammatory response to pathogenic stimulus may not be possible in the presence of chronic inflammation. We investigated if a correlation exists between chronic and efficient acute inflammation.

Methods:

Design: Case control study.

Setting: Homeopathic medical practices in 4 countries

Patients with definite improvement in chronic inflammatory conditions with at least 6 months of follow up were selected as cases. Age matched controls involved those who did not improve.

Event of interest: Occurrence of common acute infectious diseases with fever during the follow up period.

Statistical analysis: Odds Ratio of improvement in the chronic condition, with development of acute infectious diseases with fever was calculated.

Graphs were plotted to study this correlation in individual cases.

Results:

20 cases and 20 age matched controls were selected. Average age was 28.4 and 27.9 years respectively. 18/20 cases and 4/20 controls developed common infectious diseases with fever during the follow up period. Odds Ratio of the chronic condition improving, with development of acute infectious diseases with fever was 36 (95 %, CI: 5.7973 to 223.5513), z statistic: 3.846 and significance level was p = 0.0001.

Graphs of individual cases showed distinct patterns confirming the same.

Conclusions:

In this case control study, appearance of common acute infectious diseases with fever during treatment was strongly associated with improvement in the chronic inflammatory conditions. Larger studies are needed to further establish the correlation.

 

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