urging, although character of urine did not seem to be changed. The menses appeared several days sooner than expected, and were much too free, rather dark in colour, and painful. During the provings most of the experimenters were excessively nervous, with dull, stupid feeling during day and restless sleep at night. After a few days they suffered much from chilliness, as if insufficiently clothed, but did not seem to have any fever or any unusual thirst. There was muscular twitching in various parts of the body, as if cramps were setting in, but this did not occasion much inconvenience.