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Materia Medica Viva Volume 3 – page 564

To review the stages of the Arsenicum pathology: the first stage emphasizes the physical symptoms, the fastidiousness, and the miserliness; in the second stage there is increasing emphasis on the insecurities, dependency, anxiety about health, anxiety over losing others, the fear of being alone, and the fear of death; gradually the fear of death becomes an obsessive, anguishing fear – the cental issue of the person’s life. Then the third stage supervenes.
In the third stage, the constant fear and anxiety finally exhaust the patient; he eventually surrenders to his exhaustion and subsequently falls prey to a state of despair. Arsenicum appears in bold print in the rubric "despairs of recovery." There are two reasons for this despair: the first is the realization that certain symptoms he suffers may be permanent. Even if these symptoms are relatively minor, he may still experience profound despair. Secondly, he may come to despair as a consequence of the toll exacted by the weight of the constant anxiety and fearfulness that have pervaded his life. His chronic mental suffering can cause him to begin to loathe his life and to despair of ever being able to comfortably enjoy life.
It is to this stage that Arsenicum cases of anorexia nervosa belong. These cases have a withered, wrinkled, old appearance; they are prostrated, feel cold all over, and suffer from an inability to eat or to retain any amount of food. They think that food is not good for them, that no type of food is healthy enough. There is much delusionary thinking in these cases. Delusions may alternate with a state of sleepy, partial confusion. They speak seldom and abruptly, giving foolish answers and making irrelevant associations. They seem confused and have the feeling that they are going insane.
In the final stage the Arsenicum loathing of life becomes absolute; the sadness is tremendous, and suicidal depression may supervene. This depression must be taken seriously for Arsenicum is one of the truly suicidal remedies. During this stage he avoids meeting friends because he imagines that he has offended them in the past. He lies in bed, occupied with thoughts that aggravate his depression and torment his mind night and day. He feels he is incurable, and thoughts of death constantly occupy his mind. The Arsenicum patient may develop despair and a suicidal disposition quite suddenly after a severe fright or shock or even during asthmatic attacks. A sudden fear may can come that he may be forced to commit suicide Also, a depression that is similar to that of Natrum sulphuricum may result from a blow to the head.