…she took a 7th dose, and in 15 minutes had a feeling of impending death, could not speak, gasped for breath, pallor intense, dilated pupils; limbs became quite rigid, heart palpitated; she felt utterly powerless, and broke into profuse perspiration. By aid of fresh air, stimulants, etc., the attack passed off in 15 minutes, leaving her very prostrate, with ringing sounds in ears. (Lancet, 1891)
she soon experienced a feeling of complete prostration, her limbs became powerless though not rigid, she felt as if she was sinking through the bed, and thought she was dying; there was a slight perspiration, breathing was faint and shallow and she was nearly pulseless. Mustard, heat and stimulants brought her around, but she was very weak for many days afterwards.(Lancet, 1891)
…a medical man took a gram of exalgine at 9:30 p.m., and 3/4 hour later 2 grams more in a little whiskey. Shortly afterwards he complained of a little giddiness, and several times said that his head felt so large it seemed to occupy the whole room. He continued, however, playing cards until 11:00, when without warning, he collapsed in his arm-chair, prostrate, quite unable to speak or move, and gasping for breath. He continued in this state for over 1/2 hour, when he got slightly better, and said a few words between his gasps; he said he was not strong enough to move, and felt each breath a fearful effort. In this condition, he was carried up to his bedroom and laid down; but feeling unable to breathe lying down, was placed in an arm-chair well covered up before the fire. His respiration became painful to witness; he seized and clenched the hands of those around him, he was in many respects just like a man suffering from a bad attack of asthma. Respiration was 38, gasping and shallow; pulse quiet, rather weak; surface very cold, face pale but not cyanosed. Was relieved in 2 hours after vomiting a little whiskey, but remained sick, giddy and weak, and for an hour suffered from frequent and painful strangury. He then got to bed and slept
well The day following he was slightly jaundiced. During the paroxysm, he felt no
pain, but numbness all over, and as though diaphragm had stopped working, and he must go on breathing on his own account at any cost. He is not at all subject to asthma.(Brit. Med. Journal, 1890).