The acetanilid poisoning may be acute or chronic (the latter is the more frequent type) but in both cases the main effect is a general depression and weakening.
Acetanilidum patients are usually very prostrated, anemic, pale, or cyanotic and in chronic illnesses sometimes also without appetite, lean and emaciated.
They are susceptible to cold and even the temperature of their body may be below normal.
Frequently they complain of shortness of breath with rapid and shallow respiration, difficulty in breathing, especially during exertion and the dyspnea may even produce a feeling as of impending death.
The cardiovascular system of these patients is often disturbed/depressed as well. The cardiac activity may be weakened, in some cases the feet or ankles are oedematously swollen and the blood pressure is mostly very low. Together with the anemia that is one of the reasons why headaches, vertigo with singing in the ears and throbbing in the temples, weariness and powerlessness occur so frequently. The pulse is usually rapid, weak and often irregular but particularly if the dilatation of the blood vessels is marked and a shock-condition ensues, a very slow or not countable pulse may also be possible.
Fainting spells and especially collapse with coldness of the body, perspiration, paleness and the above described cyanosis are typical symptoms of Acetanilidum.
In some cases the renal function is seriously impaired. The urine is sometimes brownish in color and may contain methemoglobin, albumin, casts, and red blood cells and hematuria, oliguria or anuria may ensue.
Also the eyes are sometimes affected. The pupils can be large or small although mydriasis seems to be more frequent. On the eyeground one sees in some cases a pale optic disc with shrinking retinal vessels and the visual field may be contracted.
Other possible symptoms are for example sleeplessness, lack of appetite, digestive disturbances and jaundice.
In severe intoxication excitement and delirium followed by depression, stupor, and somnolence may occur, even respiratory paralysis and terminal asphyxial convulsions have been observed. The death of the patient is usually preceeded by a period of collapse and coma, and occurs suddenly or may be delayed for several days.
Until now, Acetanilidum has been used only extremely seldom. Many of its specific symptoms are almost unknown and also in homeopathic literature the description of this remedy is only very incomplete. Therefore it is certainly of service to report of some acute poisoning cases which have been caused by an overdose of methylacetanilid (exalgine), a derivative of acetanilid which has, according to J.H. Clarke, an almost identical action.
The first symptoms noticed were blueness of lips and cheeks, and small compressible pulse; she felt sick and giddy, sight was indistinct, and there was a feeling of weight at the epigastrium. Amyl nitrite was given by inhalation, but this increased the cyanosis. After five hours the patient vomited, followed by still a further increase of cyanosis and delirium, with frothy salivation. The temperature rose to 99.8F, pulse to 144, small and compressible, but regular….(Brit. Med. Hournal, 1890)