Randomised Controlled Trial of Homoeopathy versus Placebo in Perennial Allergic Rhinitis with Overview of Four Trial Series.
IACH - Prof. G. Vithoulkas
Randomised Controlled Trial of Homoeopathy versus Placebo in Perennial Allergic Rhinitis with Overview of Four Trial Series.
  • Author(s)

    Taylor MA, Reilly D, Llewellan-Jones RH, McSharry C, Aitchison TC.

    Journal

    British Medical Journal, 2000, 321, 471-476, 19 August.

    Notes

    51 people suffering from allergic rhinitis were randomly assigned either homeopathically potentised allergens or placebo. Those given the medicine experienced significant relief over those assigned the placebo.

    Abstract

    OBJECTIVE:

    To test the hypothesis that homoeopathy is a placebo by examining its effect in patients with allergic rhinitis and so contest the evidence from three previous trials in this series.

    DESIGN:

    Randomised, double blind, placebo controlled, parallel group, multicentre study.

    SETTING:

    Four general practices and a hospital ear, nose, and throat outpatient department.

    PARTICIPANTS:

    51 patients with perennial allergic rhinitis.

    INTERVENTION:

    Random assignment to an oral 30c homoeopathic preparation of principal inhalant allergen or to placebo.

    MAIN OUTCOME MEASURES:

    Changes from baseline in nasal inspiratory peak flow and symptom visual analogue scale score over third and fourth weeks after randomisation.

    RESULTS:

    Fifty patients completed the study. The homoeopathy group had a significant objective improvement in nasal airflow compared with the placebo group (mean difference 19.8 l/min, 95% confidence interval 10.4 to 29.1, P=0.0001). Both groups reported improvement in symptoms, with patients taking homoeopathy reporting more improvement in all but one of the centres, which had more patients with aggravations. On average no significant difference between the groups was seen on visual analogue scale scores. Initial aggravations of rhinitis symptoms were more common with homoeopathy than placebo (7 (30%) v 2 (7%), P=0.04). Addition of these results to those of three previous trials (n=253) showed a mean symptom reduction on visual analogue scores of 28% (10.9 mm) for homoeopathy compared with 3% (1.1 mm) for placebo (95% confidence interval 4.2 to 15.4, P=0.0007).

    CONCLUSION:

    The objective results reinforce earlier evidence that homoeopathic dilutions differ from placebo.

    Category: Human Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/10948025

input:focus, select:focus, textarea:focus { border-color: #bd2626; } a { color: #bd2626; } .radio i, .checkbox i { color: #bd2626; } .radio i:before { background-color: #bd2626; } .button, .btn-default { border-color: #bd2626; background-color: #bd2626; } .button:hover { color: #bd2626; } .page-header-top { background-color: #bd2626; } .page-header-bottom-alt { background-color: #bd2626; } .page-intro:after { background-color: #bd2626; } .page-intro:before { background-color: #bd2626; } .page-content-section-bg { background-color: #bd2626; } .page-content-section-bg:before { background-color: #bd2626; } .page-content-section-border { border-top-color: #bd2626; } .page-footer { background-color: #bd2626; } .block-head-1 { border-bottom-color: #bd2626; } .block-head-1 i { background-color: #bd2626; } .block-head-2:after { background-color: #bd2626; } .block-head-2 i:after, .block-head-2 i:before { background-color: #bd2626; } .block-head-3 { border-bottom-color: #bd2626; } .block-head-3 i:after { background-color: #bd2626; } .block-head-4:after { background-color: #bd2626; } .block-head-7 { border-bottom-color: #bd2626; } .block-head-7:after { background-color: #bd2626; } .page-content-section-bg .block-head-3 i { color: #bd2626; } .main-search button { color: #bd2626; } .main-search button:after { background: #bd2626; } .main-nav li a { color: #bd2626; } .main-nav li a:before { background-color: #bd2626; } .main-nav li ul { background-color: #bd2626; } .main-nav li li:hover > a, .main-nav li li.active > a, #block-newsletter-newsletter-subscribe .form-submit:hover, .block-product-details .add-wishlist .button-alt:hover, .block-product-details-2 .add-wishlist .button-alt:hover { color: #bd2626; } .main-nav .switcher { border-color: #bd2626; background-color: #bd2626; } .main-nav .mega > div { background-color: #bd2626; } #block-newsletter-newsletter-subscribe .form-submit, .btn-primary:hover, .btn-primary:focus, .btn-primary:active { border-color: #bd2626; background-color: #bd2626; } .art-portfolio ol li.active, .ui-slider-horizontal .ui-slider-handle, .ui-slider-horizontal .ui-slider-range, .btn-primary.link { background-color: #bd2626; } .btn-primary, .button:hover, .btn-default:hover, .btn-default:focus, .btn-default:active { border-color: #bd2626; color: #bd2626; } .btn-primary.link:hover, .btn-primary.link:focus, .btn-primary.link:active { color: #bd2626; } } @media screen and (max-width: 767px) { /* phone */ .main-nav ul { background-color: #bd2626; } .main-nav li a { color: #ecf0f1; } .main-nav li ul { background: #e9e9e9; } .main-nav li li { border-top-color: #bd2626; } .main-nav li li a { color: #bd2626; } .main-nav li li a:hover { background-color: #bd2626; color: #fff; } .main-nav li li ul { border-top-color: #bd2626; } .main-nav .mega ul li { border-top-color: #bd2626; } } .slider-revolution .fa:after { background-color: #bd2626; } .slider-revolution .title { border-top-color: 1px solid #bd2626; border-bottom-color: 1px solid #bd2626; } .slider-revolution .button-my { border-color: #bd2626; background-color: #bd2626; } .slider-revolution .button-my:hover { color: #bd2626; } .pagination-1 a:hover { border-color: #bd2626; color: #bd2626; } .pagination-1 .active, .pagination-1 .active:hover { border-color: #bd2626; background: #bd2626; } .pagination-2 a:hover { color: #bd2626; } .pagination-2 .active, .pagination-2 .active:hover { background: #bd2626; } .pagination-3 a:before { box-shadow: inset 0 0 0 1px #bd2626; } .pagination-3 .active:before, .pagination-3 .active:hover:before { background: #bd2626; } .pagination-4 a:hover { border-color: #bd2626; } .pagination-4 .active { border-color: #bd2626; background: #bd2626; } .pagination-5 a { border-color: #bd2626; background-color: #bd2626; color: #bd2626; } .block-benefits div:hover { border-color: #bd2626; background-color: #bd2626; } .block-benefits i { color: #bd2626; } .block-benefits-2 li i { color: #bd2626; } .block-benefits-2 .tabs a:hover { border-color: #bd2626; background-color: #bd2626; } .block-benefits-2 .tabs .active a, .block-benefits-2 .tabs .active a:hover { color: #bd2626; } .block-benefits-3 i { color: #bd2626; } .block-about .button { border-color: #bd2626; color: #bd2626; } .block-about .button:hover { background: #bd2626; color: #ecf0f1; } .block-about .owl-prev:hover, .block-about .owl-next:hover { color: #bd2626; } .block-about-2 .bar { background: #bd2626; } .block-about-2 .value { color: #bd2626; } .block-about-4 .owl-pagination div { border-color: #bd2626; background: #bd2626; } .block-about-5 .owl-prev, .block-about-5 .owl-next { display: inline-block; border-color: #bd2626; background-color: #bd2626; } .block-about-5 .owl-prev:hover, .block-about-5 .owl-next:hover { color: #bd2626; } .block-about-6 .icons a:hover { color: #bd2626; } .block-mission .year { background: #bd2626; } .block-mission .years a:after { border-bottom-color: #bd2626; } .block-recent-works ol li:hover { color: #bd2626; } .block-recent-works ol .active { border-color: #bd2626; background: #bd2626; } .block-recent-works .description { background: #bd2626; } .block-recent-works .description:before { border-right-color: #bd2626; } .block-recent-works-3 h3 { border-top-color: #bd2626; } .block-recent-works-3 .link { border-color: #bd2626; } .block-recent-works-3 .fancybox { background-color: #bd2626; } .block-recent-works-3 .owl-pagination div { border-color: #bd2626; background: #bd2626; } .block-recent-works-4:before { background: #bd2626; } .block-recent-works-4 .fancybox { background: #bd2626; } .block-recent-works-4 .owl-prev:hover, .block-recent-works-4 .owl-next:hover { color: #bd2626; } .block-recent-works-6 a:before { background: #bd2626; } .block-recent-works-6 .owl-prev, .block-recent-works-6 .owl-next { border-color: #bd2626; background: #bd2626; } .block-recent-works-6 .owl-prev:hover, .block-recent-works-6 .owl-next:hover { color: #bd2626; } .block-portfolio ol li:hover { color: #bd2626; } .block-portfolio ol li.active { border-bottom-color: #bd2626; } .block-portfolio ul .pic span:after, .block-portfolio ul .pic span:before { background: #bd2626; } .block-portfolio ul .pic span i { color: #bd2626; } .block-portfolio-2 ol li:hover { color: #bd2626; } .block-portfolio-2 ol li.active { background: #bd2626; } .block-portfolio-2 ul .pic:before { background: #bd2626; } .block-portfolio-2 ul .pic a { background: #bd2626; } .block-portfolio-2 ul .pic a:hover { color: #bd2626; } .block-portfolio-3 ol li:hover { color: #bd2626; } .block-portfolio-3 ol li.active { background: #bd2626; } .block-portfolio-4 h3 { border-top-color: #bd2626; } .block-portfolio-4 .link { border-color: #bd2626; } .block-portfolio-4 .fancybox { background: #bd2626; } .block-portfolio-5 ol li:hover { color: #bd2626; } .block-portfolio-5 ol li.active { background: #bd2626; } .block-portfolio-5 .info:before { background: #bd2626; } .block-portfolio-6 ol li:hover { color: #bd2626; } .block-portfolio-6 ol li.active { background: #bd2626; } .block-portfolio-6 ul a:before { background: #bd2626; } .block-portfolio-7 ol li:hover { color: #bd2626; } .block-portfolio-7 ol li.active { background: #bd2626; } .block-portfolio-7 ul li:before { background: #bd2626; } .block-portfolio-7 ul a:hover { color: #bd2626; } .block-portfolio-8 li div:before { background: #bd2626; } .block-portfolio-8 li a { background: #bd2626; } .block-clients .owl-prev, .block-clients .owl-next { color: #bd2626; } .block-testimonials-3 .carousel h3 { border-bottom-color: #bd2626; } .block-testimonials-3 .owl-pagination div { border-color: #bd2626; } .block-testimonials-3 .owl-pagination .active { background: #bd2626; } .block-testimonials-4 .owl-prev, .block-testimonials-4 .owl-next { border-color: #bd2626; background: #bd2626; } .block-testimonials-4 .owl-prev:hover, .block-testimonials-4 .owl-next:hover { color: #bd2626; } .block-services li a { border-color: #bd2626; } .block-services li a:hover { background-color: #bd2626; } .block-services-2 li a:hover { background: none; } .block-services-2 li a:after { box-shadow: inset 0 0 0 2px #bd2626; } .block-services-2 li a:hover:after { background-color: #bd2626; } .block-services-3 li a:hover { background: none; } .block-services-3 li a:after { box-shadow: inset 0 0 0 2px #bd2626; } .block-services-3 li a:before { background: #bd2626; box-shadow: inset 0 0 0 2px #bd2626; } .block-services-3 li a:hover:after { background-color: #bd2626; } .block-services-4 li a { border-color: #bd2626; } .block-services-4 li a:hover { background-color: #bd2626; } .block-services-5 li i { color: #bd2626; } .block-services-5 li i:hover { background: #bd2626; } .block-services-6 h3 span { color: #bd2626; } .block-services-6 li a { border-color: #bd2626; background: #bd2626; } .block-services-6 li a:hover { color: #bd2626; } .block-services-7 .info i { background: #bd2626; } .block-services-7 .carousel .active { background: #bd2626; } .block-services-7 .carousel .owl-prev, .block-services-7 .carousel .owl-next { border-color: #bd2626; background: #bd2626; } .block-services-7 .carousel .owl-prev:hover, .block-services-7 .carousel .owl-next:hover { color: #bd2626; } .block-pricing dt { color: #bd2626; } .block-pricing .price:before { background: #bd2626; } .block-pricing li:hover .inner { background: #bd2626; } .block-pricing li:hover .button { color: #bd2626; } .block-pricing li:hover .button:hover { background: #bd2626; } .page-content-section .block-pricing .inner { box-shadow: 0 0 0 1px #bd2626; } .block-pricing-2 dt { color: #bd2626; } .block-pricing-2 .price { background: #bd2626; } .block-pricing-2 .button { color: #bd2626; } .block-pricing-2 li:hover .inner { background: #bd2626; } .block-pricing-2 li:hover .button:hover { background: #bd2626; } .block-progress li i { border-color: #bd2626; color: #bd2626; } .block-team-2 .pic:before { background-color: #bd2626; } .block-team-2 .icons a { color: #bd2626; } .block-team-3 .pic:before { background-color: #bd2626; } .block-team-3 .icons a { color: #bd2626; } .block-team-3 .info h3 { color: #bd2626; } .block-team-list .pic span:after { background-color: #bd2626; } .block-team-list .icons a:hover { color: #bd2626; } .block-team-list .icons a:before { background: #bd2626; } .block-team-list .skills { border-top-color: #bd2626; border-bottom-color: #bd2626; } .block-team-grid .pic:before { background-color: #bd2626; } .block-skills i:before { background-color: #bd2626; } .block-skills .bar { border-color: #bd2626; background-color: #bd2626; } .block-skills-2 i:before { background-color: #bd2626; } .block-skills-2 .bar { border-color: #bd2626; background-color: #bd2626; } .block-capabilities h3 { color: #bd2626; } .block-capabilities-2 h3 { color: #bd2626; } .block-recent-posts .info { background-color: #bd2626; } .block-recent-posts-2:before { background-color: #bd2626; } .block-recent-posts-2 li .button { color: #bd2626; } .block-recent-posts-2 li .button:hover { background-color: #bd2626; } .block-recent-posts-2 .button-more { color: #bd2626; } .block-recent-posts-2 .button-more:hover { background-color: #bd2626; } .block-featured-posts .pic:before { background-color: #bd2626; } .block-blog-list .link { background: #bd2626; } .block-blog-list .date:before { background-color: #bd2626; } .block-blog-list .date-alt { background-color: #bd2626; } .block-blog-list .zoom { background-color: #bd2626; } .block-blog-grid .link { background: #bd2626; } .block-blog-grid .date:before { background-color: #bd2626; } .block-blog-grid .pic:hover .date { color: #bd2626; } .block-blog-grid .zoom { color: #bd2626; } .block-blog-details .date:before, .block-blog-details .reply:before, .block-blog-details .type:before { background-color: #bd2626; } .block-blog-details .date-alt { background-color: #bd2626; } .block-blog-details .share a:before { border-color: #bd2626; background: #bd2626; } .block-blog-details .share a:hover { color: #bd2626; } .block-blog-details .about:before { background: #bd2626; } .block-catalog-toolbar .view a:hover { border-color: #bd2626; color: #bd2626; } .block-catalog-toolbar .view .active, .block-catalog-toolbar .view .active:hover { border-color: #bd2626; background: #bd2626; } .block-catalog-toolbar .direction { border-color: #bd2626; background: #bd2626; } .block-catalog-toolbar .direction:hover { color: #bd2626; } .block-catalog-grid .pic:before { background: #bd2626; } .block-catalog-grid .badge { background: #bd2626; } .block-catalog-grid .price { color: #bd2626; } .block-catalog-grid .owl-prev, .block-catalog-grid .owl-next { border-color: #bd2626; background: #bd2626; } .block-catalog-grid .owl-prev:hover, .block-catalog-grid .owl-next:hover { color: #bd2626;; } .block-catalog-list .pic:after { background-color: #bd2626; } .block-catalog-list .badge:before { background-color: #bd2626; } .block-catalog-list .price { color: #bd2626; } .block-catalog-list .owl-prev, .block-catalog-list .owl-next { border-color: #bd2626; background-color: #bd2626; } .block-catalog-list .owl-prev:hover, .block-catalog-list .owl-next:hover { color: #bd2626;; } .block-product-details .price { color: #bd2626; } .block-product-details .button-alt { color: #bd2626; } .block-product-details-2 .button-alt { color: #bd2626; } .block-product-details-2 .share a:before { background-color: #bd2626; box-shadow: 0 0 0 2px #bd2626; } .block-product-details-2 .share a:hover { color: #bd2626; } .block-product-info .owl-prev, .block-product-info .owl-next { border-color: #bd2626; background-color: #bd2626; } .block-product-info .owl-prev:hover, .block-product-info .owl-next:hover { color: #bd2626; } .block-product-tabs .head .active { color: #bd2626; } .block-product-tabs .head .active:before { border-top-color: #bd2626; } .block-shopping-cart th { border-top-color: #bd2626; color: #bd2626; } .block-shopping-cart .price { color: #bd2626; } .block-shopping-cart .remove { border-color: #bd2626; background-color: #bd2626; } .block-shopping-cart .remove:hover { color: #bd2626; } .block-shopping-cart .quantity a { color: #bd2626; } .block-shopping-cart .empty td { border-bottom-color: #bd2626; } .block-shopping-cart-totals dd { color: #bd2626; } .block-shopping-cart-totals .button-alt { color: #bd2626; } .block-checkout-order td:last-child { color: #bd2626; } .block-checkout-payment label { color: #bd2626; } .block-welcome .icons i:after { border-color: #bd2626; background: #bd2626; } .block-welcome .icons a:hover i { color: #bd2626; } .block-pasteboard:before { background: #bd2626; } .block-pasteboard .icons a:hover { color: #bd2626; } .block-map-3 .block-head { color: #bd2626; } .block-contacts ul li:after, .block-contacts ul li:before { border-color: #bd2626; background-color: #bd2626; } .block-contacts ul li:before { background-color: #fff; } .block-contacts ul li span { border-bottom-color: #bd2626; } .block-contacts ul .active { color: #bd2626; } .block-contacts ul .active:before { background-color: #bd2626; } .block-contacts ol { border-top-color: #bd2626; } .block-contacts ol li { color: #bd2626; } .block-contacts ol li i:after { background-color: #bd2626; } .block-feedback .message i, .block-feedback-2 .message i { color: #bd2626; } .block-not-found h3 { color: #bd2626; } .block-not-found .pic:before { background-color: #bd2626; } .block-not-found .pic div:before { background-color: #bd2626; } .block-not-found-2 .button { color: #bd2626; } .block-not-found-2 .button:hover { background: #bd2626; } .block-coming-soon li:before { background-color: #bd2626; } .block-coming-soon-2 li:after { background-color: #bd2626; } .widget-categories a:hover, .widget-categories a.active { color: #bd2626; } .widget-top-posts a:hover { color: #bd2626; } .widget-text hr { border-top-color: #bd2626; } .widget-text em { color: #bd2626; } .widget-archive a:hover, .widget-archive a.active { color: #bd2626; } .widget-tags a:hover { color: #bd2626; } .widget-categories-filter a:hover { color: #bd2626; } .widget-categories-filter .active { color: #bd2626; } .widget-categories-filter .active span { background-color: #bd2626; } .widget-price-filter .ui-slider-range { background-color: #bd2626; } .widget-price-filter .ui-slider-handle { background-color: #bd2626; } .widget-color-filter .active:before { border-color: #bd2626; } .widget-top-products .pic i { background-color: #bd2626; } .main-nav ul { background-color: #bd2626; }