Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice.
IACH - Prof. G. Vithoulkas
Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice.
  • Author(s)

    Pathak S, Kumar Das J, Biswas S, Khuda-Bukhsh AR

    Journal

    Mol Cell Biochem. 2006 Apr;285 (1-2):121-31.

    Notes

    The researchers in this study, which was carried out at the University of Kalyani in India’s West Bengal, used 210 mice in an experiment to determine the protective effect of Lycopodium 30C against the carcinogenic effects of p-dimethyl amino azo benzene and phenobarbital. When assessed using chomosomal aberrations as well as several morphological and biochemical parameters at 120 days from the beginning of the experiment, it was confirmed that Lycopodium 30C not only exhibited a protective effect, but also a restorative effect against the action of p-dimethyl amino azo benzene and phenobarbital.

    Abstract

    The protective potentials of a potentized homeopathic drug, Lycopodium-30, prepared from extract of spores of a plant, Lyocopodium clavatum (Fam: Lycopodiaceae) and used as a remedy for various liver ailments, have been tested in mice chronically fed p-dimethyl amino azo benzene (p-DAB) - an initiator, and phenobarbital (PB) - a promoter of hepatic cancer, by using some cytogenetic endpoints like chromosome aberrations (CA), micronuclei (MN), mitotic index (MI) and sperm head abnormality (SHA), and toxicity biomarkers like acid and alkaline phosphatases (AcP and AlkP, respectively), alanine and aspartate amino transferases (ALT and AST, respectively) and lipid peroxidation (LPO) and reduced glutathione (GSH) activities. The effects of chronic treatment of the carcinogens were assessed at different intervals of fixation, namely, at day 7, 15, 30, 60, 90 and day 120, and compared with that of mice fed conjointly with the carcinogens and the homeopathic remedy. Both the assay systems indicated considerable protective potentials of the homeopathic remedy against p-DAB induced hepatocarcinogenesis in mice.

    Category: Animal Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/16538399

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