Platelet aggregation in portal hypertension and its modification by ultra-low doses of aspirin.
IACH - Prof. G. Vithoulkas
Platelet aggregation in portal hypertension and its modification by ultra-low doses of aspirin.
  • Author(s)

    Eizayaga FX, Aguejouf O, Belon P, et al.

    Journal

    Pathophysiol Haemost Thromb. 2005;34(1):29-34.

    Notes

    Researchers in this controlled study attempted to determine the effects of potentised aspirin on rats exhibiting reduced platelet aggregation associated with portal hypertension. Given that material doses of aspirin are known to be associated with a reduction in platelet aggregation, one of the aims of the study was to confirm that the reverse of this would be the case with if potentised aspirin were used. The researchers did, in fact, confirm this in their results which showed that, compared to controls, Aspirin 14C normalised deficiencies in platelet aggregation in the rats involved in this study.

     

    Abstract

    Aspirin (ASA) is widely accepted as antithrombotic drug, but several reports point out that its use in ultra-low doses (ULD) has prothrombotic properties. In this study, we evaluate the effect of portal hypertension in rats on platelet aggregation in an in vivo arterial thrombosis model induced by a laser beam. Portal hypertension was produced by calibrated stenosis of the portal vein. ASA in ULD was injected to both control and portal hypertensive groups. Platelet aggregation induced by ADP, prothrombin time, activated partial thromboplastin time, fibrinogen and induced hemorrhagic time test were also performed. Portal hypertensive rats showed a diminished number of emboli and duration of embolization in the laser procedure and an increase in induced hemorrhagic time. These changes were reverted by one injection of ASA at ULD. This observation could be of importance for primary prevention or the treatment of recurrence in upper digestive tract hemorrhage in portal hypertensive patients.

    Category: Animal Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/16293983

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