Investigating lung remodelling in Modul8 treated BALB/c asthmatic animals
IACH - Prof. G. Vithoulkas
Investigating lung remodelling in Modul8 treated BALB/c asthmatic animals
  • Author(s)

    Oberholzer HM, Pretorius E.

    Journal

    Micron, 2009, 40, 8, 775-82.

    Notes

    This trial was carried out at the faculty of Health Sciences in South Africa’s University of Pretoria and was performed to investigate what effect, if any, a specific homeopathic combination product (Module8) had against hydrocortisone, compared to a control, in mice suffering from atopic asthma. Assessment was made via the analysis of tissue structures and the numbers of eosinophils found on bronchial lavage before and after treatment. On analysis of the results noted at the end of the trial, the use of hydrocortisone and the homeopathic formula were both associated with a significant reduction in tissue structure changes and eosinophil count.

    Abstract

    Animal models of bronchial hyperresponsiveness have been successfully used to investigate the pathophysiology of asthma. When mice are sensitized and challenged with an allergen, such as OVA, they experience symptoms and processes similar to that of humans, and are therefore widely used as asthmatic animal models. In the current study the BALB/c murine asthmatic animal model was used to investigate the histological and ultrastructural changes that occur in the lungs of asthmatic animals that received no treatment, compared to two groups of asthmatic animals that were treated with a homeopathic immunodulator Modul8 and hydrocortisone as positive control, respectively. Eosinophil counts in the bronchial lavage of the animals were also analyzed, since it is known that eosinophil counts are increased in the bronchial lavage in asthma. Results indicated that eosinophil counts were elevated in asthmatic animals compared to the controls, but were found to be significantly decreased in the treatment groups. Also, in the asthmatic, untreated animals, histological and ultrastructural changes, typically associated with the inflammatory process were found. Both treatment groups compared well to that of the control animals, indicating that the homeopathic product might be successfully used in the treatment of asthma.

    Category: Animal Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/19665389

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