Efficacy of a potentized homoeopathic drug (Arsenicum album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: II. Comparative efficacy of an antibiotic, actinomycin D alone and in combination with either of two microdoses.
IACH - Prof. G. Vithoulkas
Efficacy of a potentized homoeopathic drug (Arsenicum album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: II. Comparative efficacy of an antibiotic, actinomycin D alone and in combination with either of two microdoses.
  • Author(s)

    Datta S, Mallick P, Bukhsh AR.

    Journal

    Complement Ther Med. 1999 Sep;7(3):156-63.

    Notes

    This study, carried out at the University of Kalyani in India’s West Bengal, was part of an ongoing series of trials looking at the use of homeopathically potentised arsenic to protect against the effects of exposure to material doses of arsenic, this latter being a serious health issue in several parts of India and elsewhere. The efficacy of Arsenicum album 30C and 200C have already been demonstrated to be effective against the toxicity from arsenic in previous experiments and in this particular study, the influence of the DNA transcription inhibitor, actinomycin D, on the protective effects of the homeopathic medicines was assessed. Compared to controls it was found that the use of the actinomycin D did inhibit the protective effects of Arsenicum album 30C and 200C against arsenic toxicity.

    Abstract

    OBJECTIVE:

    To determine whether actinomycin-D (AMD), an antibiotic, alters the reported efficacy of a potentized homoeopathic drug, Arsenicum Album, in reducing genotoxic effects produced in arsenic-trioxide-injected mice.

    DESIGN:

    Mice were separately injected with AMD, As2O3, and conjointly with AMD plus As2O3, AMD plus homoeopathic drug, AMD plus As2O3 plus homoepathic drug, and As2O3 plus homoeopathic drug in separate sets.

    METHODS:

    Several standard cytogenetical endpoints were assessed at different fixation intervals by adopting conventional techniques.

    RESULTS:

    Both Ars Alb-30 and Ars Alb-200 showed protective ability against AMD and As2O3 when injected individually, but this ability was reduced considerably in mice injected with AMD and As2O3 together. AMD itself had genotoxic effects, but also apparently reduced genotoxic effects of arsenic to some extent.

    CONCLUSION:

    AMD reduced the protective efficacy of the homoeopathic drug against arsenic. This result suggests a mechanism of action for homoeopathy, as AMD is a known transcription-blocker.

    Category: Animal Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/10581825

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