Efficacy of the potentized homeopathic drug, Carcinosin 200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-dimethylaminoazobenzene-induced hepatocarcinogenesis in mice.
IACH - Prof. G. Vithoulkas
Efficacy of the potentized homeopathic drug, Carcinosin 200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-dimethylaminoazobenzene-induced hepatocarcinogenesis in mice.
  • Author(s)

    Biswas SJ, Pathak S, Bhattacharjee N, Das JK, Khuda-Bukhsh AR

    Journal

    J Altern Complement Med. 2005 Oct;11(5):839-54.

    Notes

    Mice suffering from liver cancers were given either homeopathic Carcinosin 200C, or a combination of Carcinosn 200C and Chelidonium 200C over a period of 120 days, and the ability of these to ameliorate the cancers was compared to the effects of potentised alcohol over the same period of time. After the results were analysed it was found that both of the homeopathic remedies were effective in ameliorating these cancers. In addition, they were both individually effective in protecting against the development of any further hepatocarcinogenesis and the combination of the 2 homeopathic medicines were slightly more so.

    Abstract

    OBJECTIVES:

    This study was conducted to examine whether the potentized homeopathic remedy Carcinosin 200, fed alone and in combination with Chelidonium 200, has differential protective effects against p-dimethylaminoazobenzene (p-DAB)-induced hepatocarcinogenesis in mice.

    DESIGN:

    Liver tumors were induced in mice through chronic feeding of p-DAB (initiator) and phenobarbital (PB, promoter). The mice were divided into two subgroups: (1) one was fed potentized Alcohol 200 and served as controls; and (2) the other was fed Carcinosin 200 alone or in combination with Chelidonium 200 and divided into several sets. The relative efficacy of the two potentized remedies, alone or in combination, in combating hepatocarcinogenesis was assessed through several cytogenetical endpoints such as chromosome aberrations, induction of micronuclei, sperm head anomaly, and mitotic index at several intervals of fixation (days 7, 15, 30, 60, 90, and 120). Several toxicity biomarkers such as acid and alkaline phosphatases, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and lipid peroxidation activity were also assayed in three organs of treated and control mice. In addition, recovery by the homeopathic drugs, if any, of tissue damage inflicted because of chronic feeding of p-DAB and PB was also assessed by optical, scanning, and transmission electron microscopies of liver done at days 60 and 120.

    RESULTS:

    Both Carcinosin 200 and Chelidonium 200 when administered alone show considerable ameliorative effect against p-DAB-induced hepatocarcinogenesis in mice; but the conjoint feeding of these two drugs appears to have had a slightly greater protective effect.

    CONCLUSIONS:

    These homeopathic remedies have the potential to be used as complementary and alternative medicine in liver cancer therapy, particularly as supporting palliative measures.

    Category: Animal Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/16296917

input:focus, select:focus, textarea:focus { border-color: #bd2626; } a { color: #bd2626; } .radio i, .checkbox i { color: #bd2626; } .radio i:before { background-color: #bd2626; } .button, .btn-default { border-color: #bd2626; background-color: #bd2626; } .button:hover { color: #bd2626; } .page-header-top { background-color: #bd2626; } .page-header-bottom-alt { background-color: #bd2626; } .page-intro:after { background-color: #bd2626; } .page-intro:before { background-color: #bd2626; } .page-content-section-bg { background-color: #bd2626; } .page-content-section-bg:before { background-color: #bd2626; } .page-content-section-border { border-top-color: #bd2626; } .page-footer { background-color: #bd2626; } .block-head-1 { border-bottom-color: #bd2626; } .block-head-1 i { background-color: #bd2626; } .block-head-2:after { background-color: #bd2626; } .block-head-2 i:after, .block-head-2 i:before { background-color: #bd2626; } .block-head-3 { border-bottom-color: #bd2626; } .block-head-3 i:after { background-color: #bd2626; } .block-head-4:after { background-color: #bd2626; } .block-head-7 { border-bottom-color: #bd2626; } .block-head-7:after { background-color: #bd2626; } .page-content-section-bg .block-head-3 i { color: #bd2626; } .main-search button { color: #bd2626; } .main-search button:after { background: #bd2626; } .main-nav li a { color: #bd2626; } .main-nav li a:before { background-color: #bd2626; } .main-nav li ul { background-color: #bd2626; } .main-nav li li:hover > a, .main-nav li li.active > a, #block-newsletter-newsletter-subscribe .form-submit:hover, .block-product-details .add-wishlist .button-alt:hover, .block-product-details-2 .add-wishlist .button-alt:hover { color: #bd2626; } .main-nav .switcher { border-color: #bd2626; background-color: #bd2626; } .main-nav .mega > div { background-color: #bd2626; } #block-newsletter-newsletter-subscribe .form-submit, .btn-primary:hover, .btn-primary:focus, .btn-primary:active { border-color: #bd2626; background-color: #bd2626; } .art-portfolio ol li.active, .ui-slider-horizontal .ui-slider-handle, .ui-slider-horizontal .ui-slider-range, .btn-primary.link { background-color: #bd2626; } .btn-primary, .button:hover, .btn-default:hover, .btn-default:focus, .btn-default:active { border-color: #bd2626; color: #bd2626; } .btn-primary.link:hover, .btn-primary.link:focus, .btn-primary.link:active { color: #bd2626; } } @media screen and (max-width: 767px) { /* phone */ .main-nav ul { background-color: #bd2626; } .main-nav li a { color: #ecf0f1; } .main-nav li ul { background: #e9e9e9; } .main-nav li li { border-top-color: #bd2626; } .main-nav li li a { color: #bd2626; } .main-nav li li a:hover { background-color: #bd2626; color: #fff; } .main-nav li li ul { border-top-color: #bd2626; } .main-nav .mega ul li { border-top-color: #bd2626; } } .slider-revolution .fa:after { background-color: #bd2626; } .slider-revolution .title { border-top-color: 1px solid #bd2626; border-bottom-color: 1px solid #bd2626; } .slider-revolution .button-my { border-color: #bd2626; background-color: #bd2626; } .slider-revolution .button-my:hover { color: #bd2626; } .pagination-1 a:hover { border-color: #bd2626; color: #bd2626; } .pagination-1 .active, .pagination-1 .active:hover { border-color: #bd2626; background: #bd2626; } .pagination-2 a:hover { color: #bd2626; } .pagination-2 .active, .pagination-2 .active:hover { background: #bd2626; } .pagination-3 a:before { box-shadow: inset 0 0 0 1px #bd2626; } .pagination-3 .active:before, .pagination-3 .active:hover:before { background: #bd2626; } .pagination-4 a:hover { border-color: #bd2626; } .pagination-4 .active { border-color: #bd2626; background: #bd2626; } .pagination-5 a { border-color: #bd2626; background-color: #bd2626; color: #bd2626; } .block-benefits div:hover { border-color: #bd2626; background-color: #bd2626; } .block-benefits i { color: #bd2626; } .block-benefits-2 li i { color: #bd2626; } .block-benefits-2 .tabs a:hover { border-color: #bd2626; background-color: #bd2626; } .block-benefits-2 .tabs .active a, .block-benefits-2 .tabs .active a:hover { color: #bd2626; } .block-benefits-3 i { color: #bd2626; } .block-about .button { border-color: #bd2626; color: #bd2626; } .block-about .button:hover { background: #bd2626; color: #ecf0f1; } .block-about .owl-prev:hover, .block-about .owl-next:hover { color: #bd2626; } .block-about-2 .bar { background: #bd2626; } .block-about-2 .value { color: #bd2626; } .block-about-4 .owl-pagination div { border-color: #bd2626; background: #bd2626; } .block-about-5 .owl-prev, .block-about-5 .owl-next { display: inline-block; border-color: #bd2626; background-color: #bd2626; } .block-about-5 .owl-prev:hover, .block-about-5 .owl-next:hover { color: #bd2626; } .block-about-6 .icons a:hover { color: #bd2626; } .block-mission .year { background: #bd2626; } .block-mission .years a:after { border-bottom-color: #bd2626; } .block-recent-works ol li:hover { color: #bd2626; } .block-recent-works ol .active { border-color: #bd2626; background: #bd2626; } .block-recent-works .description { background: #bd2626; } .block-recent-works .description:before { border-right-color: #bd2626; } .block-recent-works-3 h3 { border-top-color: #bd2626; } .block-recent-works-3 .link { border-color: #bd2626; } .block-recent-works-3 .fancybox { background-color: #bd2626; } .block-recent-works-3 .owl-pagination div { border-color: #bd2626; background: #bd2626; } .block-recent-works-4:before { background: #bd2626; } .block-recent-works-4 .fancybox { background: #bd2626; } .block-recent-works-4 .owl-prev:hover, .block-recent-works-4 .owl-next:hover { color: #bd2626; } .block-recent-works-6 a:before { background: #bd2626; } .block-recent-works-6 .owl-prev, .block-recent-works-6 .owl-next { border-color: #bd2626; background: #bd2626; } .block-recent-works-6 .owl-prev:hover, .block-recent-works-6 .owl-next:hover { color: #bd2626; } .block-portfolio ol li:hover { color: #bd2626; } .block-portfolio ol li.active { border-bottom-color: #bd2626; } .block-portfolio ul .pic span:after, .block-portfolio ul .pic span:before { background: #bd2626; } .block-portfolio ul .pic span i { color: #bd2626; } .block-portfolio-2 ol li:hover { color: #bd2626; } .block-portfolio-2 ol li.active { background: #bd2626; } .block-portfolio-2 ul .pic:before { background: #bd2626; } .block-portfolio-2 ul .pic a { background: #bd2626; } .block-portfolio-2 ul .pic a:hover { color: #bd2626; } .block-portfolio-3 ol li:hover { color: #bd2626; } .block-portfolio-3 ol li.active { background: #bd2626; } .block-portfolio-4 h3 { border-top-color: #bd2626; } .block-portfolio-4 .link { border-color: #bd2626; } .block-portfolio-4 .fancybox { background: #bd2626; } .block-portfolio-5 ol li:hover { color: #bd2626; } .block-portfolio-5 ol li.active { background: #bd2626; } .block-portfolio-5 .info:before { background: #bd2626; } .block-portfolio-6 ol li:hover { color: #bd2626; } .block-portfolio-6 ol li.active { background: #bd2626; } .block-portfolio-6 ul a:before { background: #bd2626; } .block-portfolio-7 ol li:hover { color: #bd2626; } .block-portfolio-7 ol li.active { background: #bd2626; } .block-portfolio-7 ul li:before { background: #bd2626; } .block-portfolio-7 ul a:hover { color: #bd2626; } .block-portfolio-8 li div:before { background: #bd2626; } .block-portfolio-8 li a { background: #bd2626; } .block-clients .owl-prev, .block-clients .owl-next { color: #bd2626; } .block-testimonials-3 .carousel h3 { border-bottom-color: #bd2626; } .block-testimonials-3 .owl-pagination div { border-color: #bd2626; } .block-testimonials-3 .owl-pagination .active { background: #bd2626; } .block-testimonials-4 .owl-prev, .block-testimonials-4 .owl-next { border-color: #bd2626; background: #bd2626; } .block-testimonials-4 .owl-prev:hover, .block-testimonials-4 .owl-next:hover { color: #bd2626; } .block-services li a { border-color: #bd2626; } .block-services li a:hover { background-color: #bd2626; } .block-services-2 li a:hover { background: none; } .block-services-2 li a:after { box-shadow: inset 0 0 0 2px #bd2626; } .block-services-2 li a:hover:after { background-color: #bd2626; } .block-services-3 li a:hover { background: none; } .block-services-3 li a:after { box-shadow: inset 0 0 0 2px #bd2626; } .block-services-3 li a:before { background: #bd2626; box-shadow: inset 0 0 0 2px #bd2626; } .block-services-3 li a:hover:after { background-color: #bd2626; } .block-services-4 li a { border-color: #bd2626; } .block-services-4 li a:hover { background-color: #bd2626; } .block-services-5 li i { color: #bd2626; } .block-services-5 li i:hover { background: #bd2626; } .block-services-6 h3 span { color: #bd2626; } .block-services-6 li a { border-color: #bd2626; background: #bd2626; } .block-services-6 li a:hover { color: #bd2626; } .block-services-7 .info i { background: #bd2626; } .block-services-7 .carousel .active { background: #bd2626; } .block-services-7 .carousel .owl-prev, .block-services-7 .carousel .owl-next { border-color: #bd2626; background: #bd2626; } .block-services-7 .carousel .owl-prev:hover, .block-services-7 .carousel .owl-next:hover { color: #bd2626; } .block-pricing dt { color: #bd2626; } .block-pricing .price:before { background: #bd2626; } .block-pricing li:hover .inner { background: #bd2626; } .block-pricing li:hover .button { color: #bd2626; } .block-pricing li:hover .button:hover { background: #bd2626; } .page-content-section .block-pricing .inner { box-shadow: 0 0 0 1px #bd2626; } .block-pricing-2 dt { color: #bd2626; } .block-pricing-2 .price { background: #bd2626; } .block-pricing-2 .button { color: #bd2626; } .block-pricing-2 li:hover .inner { background: #bd2626; } .block-pricing-2 li:hover .button:hover { background: #bd2626; } .block-progress li i { border-color: #bd2626; color: #bd2626; } .block-team-2 .pic:before { background-color: #bd2626; } .block-team-2 .icons a { color: #bd2626; } .block-team-3 .pic:before { background-color: #bd2626; } .block-team-3 .icons a { color: #bd2626; } .block-team-3 .info h3 { color: #bd2626; } .block-team-list .pic span:after { background-color: #bd2626; } .block-team-list .icons a:hover { color: #bd2626; } .block-team-list .icons a:before { background: #bd2626; } .block-team-list .skills { border-top-color: #bd2626; border-bottom-color: #bd2626; } .block-team-grid .pic:before { background-color: #bd2626; } .block-skills i:before { background-color: #bd2626; } .block-skills .bar { border-color: #bd2626; background-color: #bd2626; } .block-skills-2 i:before { background-color: #bd2626; } .block-skills-2 .bar { border-color: #bd2626; background-color: #bd2626; } .block-capabilities h3 { color: #bd2626; } .block-capabilities-2 h3 { color: #bd2626; } .block-recent-posts .info { background-color: #bd2626; } .block-recent-posts-2:before { background-color: #bd2626; } .block-recent-posts-2 li .button { color: #bd2626; } .block-recent-posts-2 li .button:hover { background-color: #bd2626; } .block-recent-posts-2 .button-more { color: #bd2626; } .block-recent-posts-2 .button-more:hover { background-color: #bd2626; } .block-featured-posts .pic:before { background-color: #bd2626; } .block-blog-list .link { background: #bd2626; } .block-blog-list .date:before { background-color: #bd2626; } .block-blog-list .date-alt { background-color: #bd2626; } .block-blog-list .zoom { background-color: #bd2626; } .block-blog-grid .link { background: #bd2626; } .block-blog-grid .date:before { background-color: #bd2626; } .block-blog-grid .pic:hover .date { color: #bd2626; } .block-blog-grid .zoom { color: #bd2626; } .block-blog-details .date:before, .block-blog-details .reply:before, .block-blog-details .type:before { background-color: #bd2626; } .block-blog-details .date-alt { background-color: #bd2626; } .block-blog-details .share a:before { border-color: #bd2626; background: #bd2626; } .block-blog-details .share a:hover { color: #bd2626; } .block-blog-details .about:before { background: #bd2626; } .block-catalog-toolbar .view a:hover { border-color: #bd2626; color: #bd2626; } .block-catalog-toolbar .view .active, .block-catalog-toolbar .view .active:hover { border-color: #bd2626; background: #bd2626; } .block-catalog-toolbar .direction { border-color: #bd2626; background: #bd2626; } .block-catalog-toolbar .direction:hover { color: #bd2626; } .block-catalog-grid .pic:before { background: #bd2626; } .block-catalog-grid .badge { background: #bd2626; } .block-catalog-grid .price { color: #bd2626; } .block-catalog-grid .owl-prev, .block-catalog-grid .owl-next { border-color: #bd2626; background: #bd2626; } .block-catalog-grid .owl-prev:hover, .block-catalog-grid .owl-next:hover { color: #bd2626;; } .block-catalog-list .pic:after { background-color: #bd2626; } .block-catalog-list .badge:before { background-color: #bd2626; } .block-catalog-list .price { color: #bd2626; } .block-catalog-list .owl-prev, .block-catalog-list .owl-next { border-color: #bd2626; background-color: #bd2626; } .block-catalog-list .owl-prev:hover, .block-catalog-list .owl-next:hover { color: #bd2626;; } .block-product-details .price { color: #bd2626; } .block-product-details .button-alt { color: #bd2626; } .block-product-details-2 .button-alt { color: #bd2626; } .block-product-details-2 .share a:before { background-color: #bd2626; box-shadow: 0 0 0 2px #bd2626; } .block-product-details-2 .share a:hover { color: #bd2626; } .block-product-info .owl-prev, .block-product-info .owl-next { border-color: #bd2626; background-color: #bd2626; } .block-product-info .owl-prev:hover, .block-product-info .owl-next:hover { color: #bd2626; } .block-product-tabs .head .active { color: #bd2626; } .block-product-tabs .head .active:before { border-top-color: #bd2626; } .block-shopping-cart th { border-top-color: #bd2626; color: #bd2626; } .block-shopping-cart .price { color: #bd2626; } .block-shopping-cart .remove { border-color: #bd2626; background-color: #bd2626; } .block-shopping-cart .remove:hover { color: #bd2626; } .block-shopping-cart .quantity a { color: #bd2626; } .block-shopping-cart .empty td { border-bottom-color: #bd2626; } .block-shopping-cart-totals dd { color: #bd2626; } .block-shopping-cart-totals .button-alt { color: #bd2626; } .block-checkout-order td:last-child { color: #bd2626; } .block-checkout-payment label { color: #bd2626; } .block-welcome .icons i:after { border-color: #bd2626; background: #bd2626; } .block-welcome .icons a:hover i { color: #bd2626; } .block-pasteboard:before { background: #bd2626; } .block-pasteboard .icons a:hover { color: #bd2626; } .block-map-3 .block-head { color: #bd2626; } .block-contacts ul li:after, .block-contacts ul li:before { border-color: #bd2626; background-color: #bd2626; } .block-contacts ul li:before { background-color: #fff; } .block-contacts ul li span { border-bottom-color: #bd2626; } .block-contacts ul .active { color: #bd2626; } .block-contacts ul .active:before { background-color: #bd2626; } .block-contacts ol { border-top-color: #bd2626; } .block-contacts ol li { color: #bd2626; } .block-contacts ol li i:after { background-color: #bd2626; } .block-feedback .message i, .block-feedback-2 .message i { color: #bd2626; } .block-not-found h3 { color: #bd2626; } .block-not-found .pic:before { background-color: #bd2626; } .block-not-found .pic div:before { background-color: #bd2626; } .block-not-found-2 .button { color: #bd2626; } .block-not-found-2 .button:hover { background: #bd2626; } .block-coming-soon li:before { background-color: #bd2626; } .block-coming-soon-2 li:after { background-color: #bd2626; } .widget-categories a:hover, .widget-categories a.active { color: #bd2626; } .widget-top-posts a:hover { color: #bd2626; } .widget-text hr { border-top-color: #bd2626; } .widget-text em { color: #bd2626; } .widget-archive a:hover, .widget-archive a.active { color: #bd2626; } .widget-tags a:hover { color: #bd2626; } .widget-categories-filter a:hover { color: #bd2626; } .widget-categories-filter .active { color: #bd2626; } .widget-categories-filter .active span { background-color: #bd2626; } .widget-price-filter .ui-slider-range { background-color: #bd2626; } .widget-price-filter .ui-slider-handle { background-color: #bd2626; } .widget-color-filter .active:before { border-color: #bd2626; } .widget-top-products .pic i { background-color: #bd2626; } .main-nav ul { background-color: #bd2626; }