Efficacy of Arnica in varicose vein surgery: results of a randomized, double-blind, placebo-controlled pilot study.
IACH - Prof. G. Vithoulkas
Efficacy of Arnica in varicose vein surgery: results of a randomized, double-blind, placebo-controlled pilot study.
  • Author(s)

    Wolf M, Tamaschke C, Mayer W, Heger M.

    Journal

    Forsch Komplementarmed Klass Naturheilkd. 2003 Oct;10(5):242-7.

    Notes

    In this trial homeopathic Arnica D12 (12X) was compared to placebo, to determine its effect on the size and pain of bruising after surgery. Arnica was used once prior to surgery and then 3 times a day for 2 weeks after surgery. 60 people participated in the trial and on completion it was found that Arnica reduced the size of the bruising by 76% compared to 72% for placebo and pain was reduced by 43% from arnica and by 28% from the placebo.

    Abstract

    INTRODUCTION:

    In homeopathy ARNICA is widely used as a woundhealing medication and for the treatment of hematomas.

    OBJECTIVE:

    In this pilot study the efficacy and safety of ARNICA D12 in patients following varicose vein surgery were investigated.

    DESIGN:

    Prospective, randomized, double-blind, placebo-controlled pilot trial according to ICH GCP guidelines.

    SETTING:

    The study was conducted by a surgeon at the Angiosurgical Clinic, Berlin- Buch.

    INTERVENTION:

    After randomized allocation, 60 patients received either ARNICA D12 or placebo. Start of medication occurred the evening before operation with 5 globules. On the operation day one preoperative and hourly postoperative dosages after awakening were given. On days 2-14 of the study 5 globules 3 times a day were given. OUTCOME CRITERIA: Surface (in cm(2) and using a three-point verbal rating scale) and intensity of hematomas induced by operation, complications of wound healing, and intensity of pain (five-point verbal rating scale) as well as efficacy and safety of the study medication were assessed.

    RESULTS:

    Hematoma surface was reduced (from day 7 to day 14) under ARNICA by 75.5% and under placebo by 71.5% (p = 0.4726). The comparison of hematoma surface (small, medium, large) using the verbal rating scale yielded a value of p = 0.1260. Pain score decreased by 1.0 +/- 2.2 points under ARNICA and 0.3 +/- 0.8 points under placebo (p = 0.1977). Remission or improvement of pain was observed in 43.3% of patients in the ARNICA group and in 27.6% of patients in the placebo group. Tolerability was rated as very good in all cases.

    CONCLUSION:

    The results of this pilot study showed a trend towards a beneficial effect of ARNICA D12 with regard to reduction of hematoma and pain during the postoperative course. For a statistically significant proof of efficacy of ARNICA D12 in patients following varicose vein surgery a larger sample size is necessary.

    Category: Human Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/14605480

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