Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium sulphuricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study.
IACH - Prof. G. Vithoulkas
Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium sulphuricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study.
  • Author(s)

    Datta SS, Mallick PP, Rahman Khuda-Bukhsh AA.

    Journal

    BMC Complement Altern Med. 2001;1:9.

    Notes

    In a similar study to that described above, researchers again tested the hypothesis that the homeopathically potentised version of a potentially toxic substance could protect against the effects of the substance from which it’s derived. In this case, the protective effects of homeopathic Cadmium sulph 30C and 200C were used in an attempt to control the genotoxic effects of cadmium in mice exposed to this element. When the results of this study were analysed it was found that the homeopathic medicine did provide a statistically significant protective action against the effects of cadmium.

     

    Abstract

    Background

    Cadmium poisoning in the environment has assumed an alarming problem in recent years. Effective antimutagenic agents which can reverse or combat cadmium induced genotoxicity in mice have not yet been reported. Therefore, in the present study, following the homeopathic principle of "like cures like", we tested the efficacy of two potencies of a homeopathic drug, Cadmium Sulphoricum (Cad Sulph), in reducing the genotoxic effects of Cadmium chloride in mice.

    Another objective was to determine the relative efficacy of three administrative modes, i.e. pre-, post- and combined pre and post-feeding of the homeopathic drugs. For this, healthy mice, Mus musculus, were intraperitoneally injected with 0.008% solution of CdCl2 @ 1 ml/100 gm of body wt (i.e. 0.8 mcg/gm of bw), and assessed for the genotoxic effects through such studies as chromosome aberrations (CA), micronucleated erythrocytes (MNE), mitotic index (MI) and sperm head anomaly (SHA), keeping suitable succussed alcohol fed (positive) and CdCl2 untreated normal (negative) controls. The CdCl2 treated mice were divided into 3 subgroups, which were orally administered with the drug prior to, after and both prior to and after injection of CdCl2 at specific fixation intervals and their genotoxic effects were analyzed.

    Results

    While the CA, MNE and SHA were reduced in the drug fed series as compared to their respective controls, the MI showed an apparent increase. The combined pre- and post-feeding of Cad Sulph showed maximum reduction of the genotoxic effects.

    Conclusions

    Both Cad Sulph-30 and 200 were able to combat cadmium induced genotoxic effects in mice and that combined pre- and post-feeding mode of administration was found to be most effective in reducing the genotoxic effect of CdCl2 followed by the post-feeding mode.

    Category: Animal Studies

    External url

    http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-1-9

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