Clastogenic potential of Ruta graveolens extract and a homeopathic preparation in mouse bone marrow cells.
IACH - Prof. G. Vithoulkas
Clastogenic potential of Ruta graveolens extract and a homeopathic preparation in mouse bone marrow cells.
  • Author(s)

    Preethi KC, Nair CK, Kuttan R.

    Journal

    Asian Pac J Cancer Prev. 2008 Oct-Dec;9(4):763-9.

    Notes

    This Indian study was carried out to determine what effects, if any, a plant extract of Ruta graveolens would exert on the bone marrow cells of mice, and whether or not a 200C homeopathic potency of the same material produced a similar effect. Both forms of Ruta plus a control were administered to separate groups of mice in for 30 days (the extract was given in 2 different concentrations) and the bone marrow cells examined. At the end of the study period, measurements indicated that when compared to controls, both the plant extract and 200th potency of Ruta were found to have produced statistically significant changes to the cellular nuclear morphology, gross cellular morphology and cellular DNA. Interestingly, a study published by the same author in 2006 found that a plant extract of Ruta and its 200C potency exhibited cytotoxicity against several common forms of tumor. The fact that both forms of Ruta will cause the same problem in healthy cells that they’re capable of curing in cells that are already in this state is a useful example of the homeopathic similia principle in action.

    Abstract

    Ruta graveolens belonging to family Rutaceae has long been traditionally used as a medicinal plant as well as a flavoring agent in food. However, very little data are available on the toxicity of the plant. This report presents evidence on the genotoxic and clastogenic potential of an extract of Ruta graveolens and Ruta 200C, a homeopathic preparation. Various types of chromosomal aberrations were noted in bone marrow cells after treatment. The percentage of aberrated cells in the 400mg/kgb.wt extract administered group was found to be 21% and with 1,000 mg/kg.b.wt it was 31%. The value for the Ruta 200C treated group was also elevated to 23% as compared to the 3%for untreated animals. In addition, bone marrow cells had higher incidence of micronuclei induction when treated with the extract (400 mg and 1,000 mg/kg body weight) and Ruta 200C for 30 days. Administration of the extract (1,000 mg/kg.b.wt) over a period of 30 days also resulted in damage to cellular DNA as evidenced by comet formation where the comet parameters such as percentage DNA in tail, tail length, tail moment of the bone marrow cells were increased several fold over control values. The comet tail moment of the bone marrow cells increased from 4.5 to 50.2 after the extract treatment. Administration of Ruta 200C for 5 consecutive days increased the tail moment to 11.7. These results indicate that Ruta graveolens and Ruta 200C may induce genotoxicity in animals.

    Category: Animal Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/19256773

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