Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study.
IACH - Prof. G. Vithoulkas
Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study.
  • Author(s)

    Widrig R, Suter A, Saller R, Melzer J.

    Journal

    Rheumatol Int. 2007 Apr;27(6):585-91.

    Notes

    Using a double-blind protocol, 204 people suffering from radiologically confirmed and symptomatically active osteoarthritis were randomly assigned to receive either topical arnica or topical ibuprofen to be applied to the area where the condition was active. The success or failure of the treatments was assessed according to functional ability of the affected part and pain intensity in this area after 21 days of continuous treatment. Assessment of the results at the end of this period found that topical arnica was as successful as topical ibuprofen for the management of osteoarthritis.

    Abstract

    The use of topical preparations for symptom relief is common in osteoarthritis. The effects of ibuprofen (5%) and arnica (50 g tincture/100 g, DER 1:20), as gel preparations in patients with radiologically confirmed and symptomatically active osteoarthritis of interphalangeal joints of hands, were evaluated in a randomised, double-blind study in 204 patients, to ascertain differences in pain relief and hand function after 21 days' treatment. Diagnosis was according to established criteria; primary endpoints were pain intensity and hand function; statistical design was as per current regulatory guidelines for testing topical preparations. There were no differences between the two groups in pain and hand function improvements, or in any secondary end points evaluated. Adverse events were reported by six patients (6.1%) on ibuprofen and by five patients (4.8%) on arnica. Our results confirm that this preparation of arnica is not inferior to ibuprofen when treating osteoarthritis of hands.

    Category: Human Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/17318618

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