Can homeopathic treatment slow prostate cancer growth?
IACH - Prof. G. Vithoulkas
Can homeopathic treatment slow prostate cancer growth?
  • Author(s)

    Jonas WB, , Gaddipati JP, , Rajeshkumar NV, et al.

    Journal

    Integr Cancer Ther. 2006 Dec;5(4):343-9.

    Notes

    This US study examined the effects of the homeopathic remedies Thuja, Sabal, Conium and Carcinosin (made from the specific prostate cancer cell line used in this trial) in vitro on prostate cancer cell cultures and in vivo on 100 rats, all of which were suffering from prostate cancer. A double blind randomised design was used for this latter part of the study. The rats were given all 4 homeopathic medicines on a sequential basis over a period of 5 weeks. The in vitro part of the study, carried out over a period of 96 hours and assessed according to tumor cell viability and gene expression, showed that the cancer cell lines were unaffected by the homeopathic medicines. When the researchers assessed the results from the in vivo aspect of the study, it was found that, compared to the controls, the rats given the homeopathic medicines showed a 23% reduction in tumor incidence and a 38% reduction in the size of prostate tumors.

    Abstract

    BACKGROUND:

    Homeopathy is a complementary medicine widely used around the world. Despite extensive use of homeopathy for cancer and other serious conditions with reported success, clinical and laboratory research has been equivocal, and no rigorous research has been done on cancer. In 1999, the US National Cancer Institute evaluated the effects of homeopathic treatment of cancer from a clinic in India and has released a request for protocols to conduct further research into this treatment. Therefore, the authors conducted a series of carefully controlled laboratory studies evaluating the effects of commonly used homeopathic remedies in cell and animal models of prostate cancer.

    STUDY DESIGN:

    One hundred male Copenhagen rats were randomly assigned to either treatment or control groups after inoculation with prostate tumor cells.

    METHODS:

    Prostate tumor cells DU-145, LNCaP, and MAT-LyLu were exposed to 5 homeopathic remedies. Male Copenhagen rats were injected with MAT-LyLu cells and exposed to the same homeopathic remedies for 5 weeks. In vitro outcomes included tumor cell viability and apoptosis gene expression. In vivo outcomes included tumor incidence, volume, weight, total mortality, proliferating cell nuclear antigen (PCNA) expression, apoptotic cell death (terminal deoxynucleotidyl transferase mediated d-uridine triphosphate nick end labeling), and gene expression (rAPO-multiprobe).

    RESULTS:

    There were no effects on cell viability or gene expression in 3 prostate cell lines with any remedies at any exposure time. There was a 23% reduction in tumor incidence (P < .0001), and for animals with tumors, there was a 38% reduction in tumor volume in homeopathy-treated animals versus controls (P < .02). At time of killing, experimental animals with tumors had a 13% lower average tumor weight (P < .05). Tumors in these treated animals showed a 19% increase in apoptotic cell death (P < .05) and reduced PCNA-positive cells.

    CONCLUSIONS:

    The findings indicate that selected homeopathic remedies for the present study have no direct cellular anticancer effects but appear to significantly slow the progression of cancer and reduce cancer incidence and mortality in Copenhagen rats injected with MAT-LyLu prostate cancer cells.

    Category: Animal Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/17101763

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