Antiviral activity of Engystol: an in vitro analysis.
IACH - Prof. G. Vithoulkas
Antiviral activity of Engystol: an in vitro analysis.
  • Author(s)

    Oberbaum M, Glatthaar-Saalmüller B, Stolt P, Weiser M.

    Journal

    J Altern Complement Med. 2005 Oct, 11, 5, 855-62.

    Notes

    Cultured tissue cells infected with herpes simplex virus 1 (HSV-1), human rhinovirus (HRV), adeno 5 (A5V) and respiratory syncytial virus were exposed to Engystol, a homeopathic combination product. These cells were then assayed for virus clearance using plaque reduction, virus titration and Elisa methods. The results of these assays showed an 80% reduction in HSV-1 specific proteins, a 73% reduction in A5V specific proteins and a reduction in infectivity of RSV by 37% and HRV by 20%.

    Abstract

    To study the effects of the homeopathic preparation Engystol (Biologische Heilmittel HEEL GmbH, Baden-Baden, Germany) on a panel [corrected] of human pathogenic viruses in vitro.

    DESIGN:

    The effects of Engystol were studied using plaque-reduction assays and virus titration assays, and by quantification of newly synthesized viral proteins in virus-specific enzyme-linked immunoabsorbent assays (ELISAs).

    SUBJECTS:

    The DNA viruses Adeno 5 and herpes simplex type 1 (HSV-1), the RNA virus respiratory syncytial virus (RSV), and human rhinovirus (HRV).

    RESULTS:

    A 73% reduction of Adeno 5 specific proteins and an 80% reduction in HSV-1 specific proteins were observed in ELISAs of virus-infected cells treated with Engystol after infection. The effects appeared to be dose-dependent. With these viruses, similar results were observed in titration assays of viral offspring from cells treated with Engystol. Pretreatment of adenovirus with Engystol did not inhibit the infectivity of the virus suspension and no Engystol-induced stimulation of interferon-alpha could be observed. Plaque-reduction assays with the RNA viruses, RSV and HRV, showed reductions in infectivity by 37% (RSV) and 20% (HRV), respectively.

    CONCLUSIONS:

    The results indicate antiviral activity of Engystol independent of the activation of the cellular interferon system.

    Category: In Vitro Studies

    External url

    https://www.ncbi.nlm.nih.gov/pubmed/16296918

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